Series V. Goodhue Family Papers includes family correspondence, Goodhue relatives' papers, Pickering and Orne family papers, and military papers. This series contains letters from Jonathan Goodhue (1744-1778) to his father while at Harvard, and letters from Benjamin (1748-1814) to his brothers. There is a letter to Stephen from his brother-in-law, James Prescott. The Goodhue relatives' papers contain documents from Goodhue family members and in-laws, such as James Prescott, Richard Wheatland, Isaac Pierce, and Gideon Tucker; also includes a lock of hair. Included are Jonathan Goodhue's (1744-1778) 1768 diary of shipping transactions, Jonathan's 1760 copy of the 1734 Harvard College Laws, and some genealogical notes of the Goodhue family by Daniel Goodhue (1759-1803). The placement of the Pickering and Orne family papers in this series was determined by Benjamin's (1707-1783) relationship to them through his two wives. Noteworthy in these papers is a 1747 deed between Timothy Pickering, Timothy and Lois Orne, William and Eunice Pickering, widow Sarah (Hardy) Mansfield, Nathaniel and Seeth (Hardy) Phippen, Jr., Isaac and Mary (Hardy) Pierce, Edmund and Lydia (Hardy) Henfield, and Benjamin and Ruth (Hardy) Ropes, and Benjamin and his wife Martha (Hardy) Goodhue. This deed reveals the many in-law relationships between these people. Also included here are the shipping papers of Timothy Orne, and a 1738 property deed from Sarah Pickering to her grandson Benjamin Goodhue for a pew.

The military papers include muster lists and accounts and receipts of Salem and Essex County Regiments for years during the French and Indian War and the Revolutionary War. Orders and bounty receipts for Captain Benjamin (1707-1783) Goodhue are the result of an expedition to Canada. Benjamin's (1748-1814) military and civic involvement in the Revolution is probably the reason for the documents relating to the Revolutionary War. Also included is a 1711 muster roll for the William Pickering Company, and a 1781 request by the men of Woodstock, Connecticut, in the Continental Army for pay.