The George Frizzell papers contain papers relating to Frizzell's participation in Admiral Richard E. Byrd's second Antarctic expedition, which took place from 1933 until 1935. The collection also contains personal papers and photographs from the expedition and Frizzell's personal life. This collection has been divided into three series.

Series I. Byrd Antarctic Expedition II contains official and personal papers relating to Richard E. Byrd's second Antarctic expedition and the barkentine Bear of Oakland. Included in this series is a journal/photograph album which Frizzell kept during the expedition; he finished compiling it when he returned home. At the beginning of the journal, Frizzell wrote down the agreement of association on joint venture of exploration to Antarctic regions that all of those involved in the expedition would have signed. The pages of the journal/photograph album have been removed from the original metal binding for preservation reasons and the original binding has been kept. There is another journal, song book, and miscellaneous notes included in this series as well. Ship's papers from the Bear of Oakland are included in this series, which include requisitions for supplies, instructions for conduct, news updates received from around the world, and a blueprint of the Bear of Oakland. Also included are invitations and programs from events held in honor of the expedition, news clippings about the expedition and Byrd, materials about the possible establishment of a Byrd Polar Center in Boston, drawings and sketches by Frizzell related to the expedition, and ephemera collected by Frizzell about the expedition.

Series II. Personal Papers contains materials not directly related to the expedition. Included in this series is correspondence, received and sent both during and after the expedition. There are also items that Frizzell collected such as maps, articles on sea horses, post cards, and other souvenirs from his travels. There is a folder of miscellaneous items which includes a booklet of questions and answers from volume one of the Mariner's Guide, and a "Supplement to General Information Concerning Patents Pamphlet."

Series III. Photographs contains photographs taken, presumably by Frizzell, while participating in Byrd's expedition and of personal photographs taken after the expedition. A few of the photographs are attributed to other people. This series has been divided into two subseries. Subseries A. Expedition contains photographs and some negatives taken during the expedition. The photographs includes scenes of and from the ships, mostly of the Bear of Oakland, and of Antarctica and Little America, the base camp. There are photographs of individuals and groups of people (some of whom are identified), the dog sled teams, wildlife, and of the hunting of wildlife. The majority of the expedition photographs are labeled but not dated. Included in this subseries are a few negatives. Subseries B. Other contains photographs of Panama and New Zealand, photographs of family members, and of other places, some of which are identified. There are also negatives of what appear to be paintings; some of these have a name on them other than Frizzell.