Daniel Epes (1622 -1692) was born in England to Daniel Epes of Kent and Martha Read of Essex. He came to Ipswich, Massachusetts from Kent with his mother after the death of his father. His mother later married Samuel Symonds. In 1646 Epes married Elizabeth Symonds, his step sister. They had eleven children. Elizabeth died in 1685; Daniel then married Lucy Woodbridge, daughter of John Woodbridge and the widow of Rev. Simon Bradstreet. Daniel died in 1692.

Samuel Epes (1647-1685) was the son of Daniel Epes and Elizabeth Symonds Epes and the brother of Symonds Epes. He graduated from Harvard College in 1669.

Symonds Epes (1662-1741) was the son of Daniel Epes and Elizabeth Symonds Epes. He was a colonel of a military regiment, a Justice of the General Sessions Court, and a member of the Governor's Council from 1724 to 1734. When he was 54 years old, he married Mary Whipple, age 16, and they had two children, Samuel (1734-1760) and Elizabeth (1736-1759). After his death, his widow, Mary, married Edward Holyoke, the President of Harvard College.

Lucy Woodbridge Epes (1641-1710) was the daughter of John Woodbridge and the widow of Reverend Simon Bradstreet before she married Daniel Epes in 1685.

Samuel Epes (1734-1760) was the son of Symonds Epes and Mary Whipple. He graduated from Harvard College at the age of seventeen, was elected a Representative at age 25, and was commander of the Third Foot Company of militia in Ipswich, holding the rank of Major. He died of consumption in Cambridge in July 1760, after a lingering sickness. The year before he died he sold the ancestral estate in Ipswich, Massachusetts, which had been in the possession of the Epes family for three generations, to John Patch III.

Elizabeth Epes (1736-1759) was the daughter of Symonds Epes and Mary Whipple. She married Edward Eveleth.