Colonel Moses Little was born on May 8, 1724, the son of Moses and Sarah Little of Newbury, Massachusetts. He married Abigail Bailey on June 5, 1743. She was the daughter of Joshua and Sarah Bailey, also of Newbury, and the sister of General Jacob Bailey, who served in the French and Indian, and Revolutionary Wars.

During his lifetime, Colonel Little acquired a great deal of land in Massachusetts, New Hampshire, Vermont, and Maine. He originally became interested in acquiring land when he served as the Surveyor of the King's Woods in the 1750s. Little was one of the original proprietors of the Pejepscot lands in Cumberland County, Maine, then a territory of Massachusetts. He eventually bought a large portion of the Pejepscot land, which remained in the Little family for about eighty years. After his death, his estate was valued at $62,356, a considerable fortune for the period.

Colonel Little played an active role in the Revolution. He represented Newbury at the Ipswich Convention in September, 1774, which met to discuss the implementation of the Massachusetts Government Act. He led a militia force from Newbury on the day that his town received word of the battles of Lexington and Concord. Little was already an experienced soldier, serving as a Captain during the French and Indian Wars. He received the commission of Colonel in the Massachusetts Militia on June 15, 1775, after several captains requested to be put under his command. The Colonel proved his leadership abilities at the Battle of Bunker Hill, where he was under constant gunfire, and also at the Battle of Long Island. In 1777, he resigned from service, due to bad health, and in 1779 refused a commission of Brigadeer General for the same reason.

Colonel Little suffered a stroke in 1781, which left him almost speechless. He still remained active in local and state government for many years until his death on May 27, 1798.

Colonel Josiah Little, the son of Colonel Moses and Abigail Little, was born on February 16, 1747. He married Sarah Toppan, the daughter of Edward and Sarah Toppan of Newbury, on March 23, 1770.

Josiah went into business with his father, and later took control of his father's real estate, most of which he eventually inherited. He also became one of the leading proprietors of the Pejepscot Company, which invested in Maine lands, and had to deal with boundary disputes and squatters on several occasions. He remained active in overseeing his property until he was past eighty years old. Josiah was also involved in shipping in Newburyport with his cousin Jacob Little.

Josiah was an active member of the Federalist Party, and served as a representative to the General Court for twenty five years, nineteen in succession. He was also an early supporter of Bowdoin College, where his son Josiah attended. He died on December 26, 1830 as a result of complications from a broken thigh.

Josiah Little Jr. was born on January 13, 1791. He was educated at Bowdoin College, graduating in 1811. On January 24, 1814, he married Sophronia Balch, the daughter of John and Eunice Balch of Newburyport.

Josiah was an extensive land owner, inheriting much of the land in Cumberland County, Maine, first acquired by his grandfather Moses. He was also involved in manufacturing of various kinds. He served two terms in the Massachusetts State Senate, and was one of the founders of the Newburyport Public Library in 1854. He held the position of Overseer of Bowdoin College from 1847 to 1858, and while there he established a professorship of Natural Science. He died without any children on February 5, 1860.

Edward Little, the son of Colonel Josiah Little, was born on March 12, 1773. He graduated from Dartmouth College in 1797, and studied law under Chief Justice Theophilus Parsons in Newburyport. On January 10, 1799 he married Hannah Brown, who died on August 1, 1828. On June 21, 1831, he married Hannah Chase, the widow of Tappin Chase of Portland, Maine.

Edward practiced law for many years as a county attorney and represented the Pejepscot Company in several legal matters. He published law reports for the Commonwealth and was a delegate to the General Court from 1805 to 1807. In 1811, Edward moved to Portland, Maine, where he became involved in the book trade. He involved himself in new industries, such as the Bath Slate Factory, in community activities, and had a particular interest in temperance reform. In 1826, he moved to Auburn, Maine, where on September 21, 1849 he died.

Captain David Little was born on April 6, 1766. His father was Stephen Little, the brother of Colonel Moses Little, and his mother was Sarah Bailey, Abigail Bailey Little's sister. He married Abigail Noyes on March 24, 1785.

David was a soldier in the Newbury militia for almost eight years, resigning his commission in 1802. He held various town Offices, such as Town Coroner an Overseer of the Poor. He also served in the State Legislature. He owned land in Newbury and Newburyport, including a large farm. He died on January 1, 1825.

Doctor Moses Little was born in Newbury on July 4, 1766. He was the son of Richard and June Little. He attended Harvard College, where he befriended John Quincy Adams, also a student there. He married Elizabeth Williams, the daughter of George Williams, a well-known merchant from Salem, on April 17, 1799.

After graduating in 1787, Moses studied medicine under Doctor Jonathan Swett of Newburyport. He settled in Salem, and had a very successful practice there. He died on October 13, 1811 of pulmonary tuberculosis, as did his wife and children.