This collection documents the business and personal activities of the noted doctor, agriculturalist, statesman, and diplomat, George Bailey Loring (1817-1891) of Salem. The papers contain descriptive patient records, kept while Loring was a surgeon at the United States Marine Hospital in Chelsea, and many of his dedicatory, political, and agricultural addresses. In addition, the collection includes political, personal, and estate papers of George B. Loring, and correspondence, diaries, and legal papers of family members. The papers are divided into four series.

Series I. United States Marine Hospital Patient Records is comprised of 22 volumes which form a nearly complete chronological run from 1843 to 1850. These important and illuminating volumes contain the names, health history, disease symptoms, dates, and nature of treatment provided to the patients Loring attended. All volumes include an index, either by patient name, or, in the case of the 1843 records, by date of hospital entrance. Noted in these pages are descriptions and treatments of such ailments as venereal disease, typhoid, rheumatism, diarrhea, pneumonia, ulcers, cancer, hepatitis, burns, measles, fractures, frostbite, epilepsy, scurvy, leprosy, insanity, intemperance, and gunshot wounds. Of interest are several lists which Loring compiled: a tabulation of the number of cases of each disease (August-November, 1844), and a selection of medicinal recipes, and disease treatments (August-November 1847).

Series II. Addresses and Lectures, 1860-1879, are divided into three chronologically arranged sections. Subseries A. New England Dedicatory and Political Addresses includes dedication and anniversary orations for towns, schools, town halls, and lyceums delivered in North Andover, Salem, Topsfield, Plymouth, Dunstable, Swansea, Sherborne, Lexington, Bolton, and Lawrence. Biographical addresses and an address made at the 1872 Republican States Convention in Worcester may also be found here. Subseries B. Agricultural Addresses includes speeches made before the New England Agricultural Society, of which Loring was president, and the Essex Agricultural Society. Subseries C. Miscellaneous Addresses includes copied speeches and chapters from New England and the rest of the country.

Series III. Business and Personal Papers contains correspondence, legal, financial, and miscellaneous papers. The correspondence illuminates events in Loring's political career and in national politics: the celebration of Thomas Jefferson's birthday (1859), including the responses of Jefferson Davis and United States Secretary of the Treasury Howell Cobb to celebration invitations; Loring's support of the Lincoln administration against the supporters of George B. McClellan (1864); the assassination attempt made on President Garfield (1881); inner political conflicts in the government, recorded while Loring was United States Commissioner of Agriculture and a United States Representative; and Loring's tenure as a United States minister to Portugal (1889-1890). The correspondence also includes personal letters regarding real estates and stock investments, the estate of William Pickman, Loring's will, and the Osgood family genealogy. Of special interest is a letter from Ralph Waldo Emerson (November 23, 1853), reflecting Loring's avid interest in literature. Loring's legal and financial papers often include or are authored by his brother, Boston attorney John Alden Loring. These records include deeds for stock, real estate, and the Pickman farm. The miscellaneous papers contain Honorable Joseph S. Cabot's speech delivered at the 1859 Thomas Jefferson celebration, poetry, eulogies on George Loring, and an undated survey of Salem property.

Series IV. Family Papers contain personal correspondence, legal records, diaries, and commonplace books belonging to Loring's wives, Mary Toppan (Pickman) (1816-1878) and Anna (Smith) Hildreth Loring, his daughter and son-in-law, Sally Pickman (Loring) and Theodore F. Dwight, and his brother, John Alden Loring (1824-1898). In addition to Mary Loring's will, this collection contains three volumes of her original diaries (1831, 1834, 1839). The volume of diary extracts (1831-1898), which includes Mary's biography, was compiled by her husband as a gift to their daughter Sally. The legal papers of Anna Loring include documents regarding the Pickman farm and court papers concerning Anna and Sally's clear title to the real estate bequeathed to them in George Loring's will. Sally (Loring) and Theodore Dwight's correspondence also discusses George Loring's estate, and the conflicts between Anna and Sally in their selection of estates trustee. Also included is a list of Sally and Theodore's wedding gifts (1895), Theodore's 1904 appointment as consular agent to Switzerland, and an undated photograph of Sally. John Alden Loring's papers include correspondence and legal papers concerning the William Pickman estate, and stock and real estate investments which he held jointly with his brother George B. Loring.